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ProjTitle.icon Types of Variations:

The variation can be categorized into two categories:

A.         Type A: Minor variations

Such minor variations does not affect the classification decision, neither require reclassification; however, a notification letter for variation could be submitted to PCD either via pcs@sfda.gov.sa or through the electronic Products Classification System (ePCS).

B.           Type B: Major variations:

Such major variations, which may have a significant impact on the classification decision and require a new classification request.

In order to facilitate the classification of variation, examples listed in appendix below are explicitly define the various types of changes.

Appendix 1; example of some major changes and most minor changes; which are categorized by the type of change.

Type of variation

Examples

Documentation

A

Minor

  • •  Change in the administrative information such as:

  •      -  Name and/or address of the manufacturer

  •      -  Transfer the product to new marketing authorization holder (different legal entity)

  • •  Change in the name of the product

  • •  Change in the name of the active substance (if available)

  • •  Change in the pack size or container type

An optional notification letter

B

Major

  • •  Change in the product's label or artwork information other than those listed as type A variation

  • •  Change in the compositions of the product (if available)

  • •  Change in the concentration of the compositions (if available)

  • •  Change in the mode of action of the product

  • •  Change in the mode of action of compositions (if available)

  • •  Change in the intended use and/or claim

  • •  Change in pharmaceutical form and rout of administration (if available)

  • •​  Change in Instruction For Use (IFU) (if available)

A new classification request**

​** Please refer to Products Classification Guidance for information on how to submit a classification request.


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